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Wilson is preparing his 14-year-old patient, Nick, for a bone marrow transplant when the donor, Nick's younger brother Matty, suddenly starts sneezing. Since Nick's immune system has been destroyed by the chemotherapy for his cancer, he cannot risk a marrow donation from Matty while Matty is ill. House decides that the fastest way to find out what's wrong with Matty is to make him worse. As the boys get sicker and sicker, House and his team race to cure Matty before both brothers die. Meanwhile, House battles Hector (his newly adopted dog) for supremacy and Foreman. A 19-year-old college student, Addie, starts coughing up blood during karate class and ends up one of House's cases. Foreman hands in his resignation before treating the woman and refuses to explain why.

Model Manual Transmission. Although her symptoms show no signs of it, House is convinced that an infection is causing Addie's bleeding. Her lungs start filling with fluid and House's team believes a toxin or cancer is to blame for Addie's illness but are unable to change House's mind.

Addie continues to get worse and House wants to do an extremely risky life-or-death treatment in order to.