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Hi everyone, I have noticed that fairly often the matter arises regarding what dosage is applicable to HUMANS when referencing the dosage(s) in a study conducted on ANIMALS. The most common instance is RODENT STUDIES wherein the dosages mentioned are applicable to either RATS or MICE; and wherein there exists the need to calculate what is the HUMAN EQUIVALENT DOSAGE (HED). Therefore, I thought I'd post here the details regarding precisely how the HED can be calculated.

In short, the relevant formula is as follows: HED (mg/kg) = Animal Dose (mg/kg) x [Animal K m / Human K m] Human K m = 37 Mouse K m = 3 Rat K m = 6 EXAMPLE: Say a STUDY conducted on MICE reports that a dosage of 5mg/kg was used; what is the HED? By calculation, the HUMAN EQUIVALENT DOSE (HED) = 5 x [3 / 37] = 0.405 mg/kg For further details see attached file ' Dose translation from animal to human studies'. Isn't the Km based on a person with the weight of 60 kg? So you (should) change it in the formula so it 'fits' your weight?

Actually, no Please kindly note that the scaling purely according to body weight is precisely what is the common mistake that needs to be avoided. K m = Body weight (kg) / Body Surface Area (BSA) (m 2) Hence, if you wanted to be absolutely accurate and adjust for weight differential then you would also need to factor in Body Surface Area (BSA) differential too. As such, to avoid matters being overcomplicated, since the K m for adult human won't in fact vary massively I would simply use the 37 figure, unless you wish to complete the more complex calculation incorporating both Body Weight and Body Surface Area (BSA) differentials Edited by ScienceGuy, 14 August 2012 - 05:01 PM.